Paracetamol (acetaminophen) plays a unique role in children because it is the first-line treatment for both fever and pain. When administered at the recommended doses, it has little negative effects and is very well tolerated. While fever alone does not require treatment, when combined with discomfort or pain, paracetamol provides relief. Paracetamol is also useful for mild to severe pain, either alone or in conjunction with another medication. Even in extreme pain, paracetamol has a strong additional analgesic impact to opioids. The paediatric dose ranges between 10 and 15 mg/kg worldwide.